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Abdulla A.-B. Badawy, Ph.D., FRCPath

Honorary Professor of Clinical Biochemistry

Cardiff School of Health Sciences

University of Wales Institute Cardiff (UWIC)

Presentations/Publications with the NRLC

Assessment of the human kynurenine pathway: Comparisons and clinical implications of ethnic and gender differences in plasma tryptophan, kynurenine metabolites, and enzyme expressions at baseline and after acute tryptophan loading and depletion.
Badawy, A. A-B., Dougherty, D. M. (2016).

International Journal of Tryptophan Research, 9, 31-49.
Standardization of formulations for the acute amino acid depletion and loading tests.
Badawy, A. A., and Dougherty, D. M. (2015).

Journal of Psychopharmacology, 29, 363-371.
Mechanisms of the pellagragenic effect of leucine: stimulation of hepatic tryptophan oxidation by administration of branched-chain amino acids to healthy human volunteers and the role of plasma free tryptophan and total kynurenines.
Badawy, A. A., Lake, S. L., Dougherty, D. M. (2014).

International Journal of Tryptophan Research, 7, 23-32.
Specificity of the acute Tryptophan and Tyrosine plus Phenylalanine depletion and loading tests Part I. Review of biochemical aspects and poor specificity of current amino acid formulations.
Badawy, A. A.-B., Dougherty, D. M., and Richard, D. M. (2010).

International Journal of Tryptophan Research, 3, 23-34.
Specificity of the acute Tryptophan and Tyrosine plus Phenylalanine depletion and loading tests Part II. Normalisation of the Tryptophan and Tyrosine plus Phenylalanine to competing amino acid ratios in a new control formulation.
Badawy, A. A.-B., Dougherty, D. M., and Richard, D. M. (2010).

International Journal of Tryptophan Research, 3, 35-47.
Activation of liver Tryptophan Pyrolase mediates the decrease in Tryptophan availability to the brain after acute alcohol consumption in normal subjects.
Badawy A. A.-B, Dougherty D. M., Marsh-Richard, D. M., and Steptoe, A. (2009).

Alcohol and Alcoholism, 44, 267-271.
Comparison of 50g and 100g L-tryptophan depletion and loading formulations for altering 5-HT synthesis: Pharmacokinetics, side effects, and mood states.
Dougherty, D. M., Marsh-Richard, D. M., Mathias, C. W., Hood, A. J., Addicott, M. A., Moeller, F. G., Morgan, C. J., and Badawy, A. A.-B. (2008).

Psychopharmacology, 198, 431-445.
The acute tryptophan depletion and loading tests: Specificity issues.
Badawy, A. A.-B., Morgan, C. J., Dougherty, D. M., Marsh, D. M., Mathias, C. W., Jagar, A. A., Addicott, M. A., and Moeller, F. G. (2007).

International Congress Series, 1304C, 159-166.
Assessment of the kynurenine pathway in humans 1. Normal plasma values, ethnic differences, and their clinical implications.
Badawy, A. A.-B., Morgan, C. J., Turner, J. A., Dougherty, D. M., Marsh, D. M., Mathias, C. W., Addicott, M. A., and Jagar, A. A. (2007).

International Congress Series, 1304C, 335-343.
The effects of alcohol on laboratory-measured impulsivity after L-Tryptophan depletion or loading.
Dougherty, D. M., Marsh, D. M., Mathias, C. W., Dawes, M. A., Bradley, D. M., Morgan, C. J., and Badawy, A. A.-B. (2007).

Psychopharmacology, 193, 137-150.