Charles W. Mathias, Ph.D.
Associate Professor
Department of Psychiatry, The University of Texas Health Science Center at San Antonio
Director of Community Outreach, Division of Neurobehavioral Research
Health Policy Fellow, class of 2019-2020, Robert Wood Johnson Foundation (RWJF)
Biographical Sketch
Dr. Mathias is Associate Professor (tenured) in the Division of Neurobehavioral Research within the Department of Psychiatry at the University of Texas Health Science Center at San Antonio (UTHSCSA).
His career as a researcher has focused on individuals whose functional status has declined to a point where they have come into contact with safety net systems: individuals expressing dangerous aggressive behavior towards others, suicidal behavior, and substance abuse that to contact with law enforcement, emergency detention, incarceration, and inpatient/residential treatment. This research tests underlying mechanisms leading to functional declines and more importantly, factors that promote restoration of function allowing for independent living outside of safety net systems.
More recently this work has included administering health services delivery for those who criminal justice involved; an alcohol treatment for adults arrested for driving while intoxicated offenses and under pretrial supervision. Additionally, through service as the behavioral health representative on the Texas Department of Transportation Impaired Driving Taskforce, he is becoming increasingly involved in policy around involvement of people with mental and substance use disorders in the criminal justice system.
His experiences with clients seeking a new life after a drunk driving arrest, relationships with county pretrial supervision working to maintain public safety, and state programs to produce innovative change has borne a commitment to policy solutions for creating measurable, sustainable progress for improving lives of those with behavioral health conditions resulting in law enforcement contact.
Research Interests
- Health Policy
- Driving While Intoxicated Arrests and Alcohol Interventions
- Adolescent Development of Impulse Control
- Developmental Course of Suicidal Behaviors
- Childhood Psychopathology, including ADHD and Conduct Disorder
- Psychophysiological Assessment
- Neuropsychological Assessment
- Characterizing Aggression
Education
Year | Degree | Major | Institution |
---|---|---|---|
2020 | Fellowship | Health Policy | Robert Wood Johnson Foundation and the National Academy of Medicine |
2004 | Fellowship | Psychopharmacology | University of Texas Health Science Center Houston |
2000 | Ph.D. | Applied Biopsychology | University of New Orleans |
1997 | M.S. | Applied Biopsychology | University of New Orleans |
1993 | B.S. | Psychology | Indiana University |
Citation Record
- 3245 Times Cited
- 40 Citations per Publication
- 30 h-index
Presentations/Publications with the NRLC
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The role of social support in motivating reductions in alcohol use: Tests of three models of social support in alcohol impaired drivers
Alcoholism: Clinical and Experimental Research, 43, 123-134.
- Laboratory measures of impulsivity.
- The correspondence between transdermal alcohol monitoring and daily self-reported alcohol consumption
- Reliability estimates for the Immediate and Delayed Memory Tasks.
- Development of a version of the self-ordered pointing task: a working memory task for Brazilian preschoolers
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Increasing Prevalence of Alcohol Use Disorders: Meeting the Challenge in Primary Care : Commentary on Williams et al., Barriers to and Facilitators of Alcohol Use Disorder Pharmacotherapy in Primary Care: A Qualitative Study in Five VA Clinics.
Journal of General Internal Medicine, DOI: 10.1007/s11606-017-4226-4
- Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol
- Preadolescent sensation seeking and early adolescent stress relate to at-risk adolescents’ substance use by age 15
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Early adolescent trajectories of impulsiveness and sensation seeking in children of fathers with histories of alcohol and other substance use disorders
Alcoholism: Clinical & Experimental Research,. 40, 2,622-2,630
- Acute effects of methylphenidate on impulsivity and attentional behavior in Comorbid ADHD and Conduct Disorder
- Child problems as a moderator of relations between maternal impulsivity and family environment in a high-risk sample.
- Pubertal maturation compression and behavioral impulsivity among boys at increased risk for substance use
- Behavioral impulsivity does not predict naturalistic alcohol consumption or treatment outcomes
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Clinical and social/environmental characteristics in a community sample of children with and without family histories of Substance Use Disorder in the San Antonio area: A descriptive study
Journal of Child and Adolescent Substance Abuse, 25, 327-339.
- Family functioning as a mediator of relations between family history of Substance Use Disorder and impulsivity
- Functional activation and effective connectivity differences in adolescent marijuana users performing a simulated gambling task
- Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance use disorders performing a go/no go task
- Increased Pre- and Early-Adolescent Stress in Youth with a Family History of Substance Use Disorder and Early Substance Use Initiation
- Childhood stress exposure among preadolescents with and without family histories of substance use disorders
- Behavioral impulsivity and risk-taking trajectories across early adolescence in youths with and without family histories of alcohol and other drug use disorders
- Effects of tryptophan depletion and a simulated alcohol binge on impulsivity.
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Rapid-response impulsivity: Definitions, measurement issues, and clinical implications
Personality Disorders: Theory, Research, and Treatment, 6, 168-181.
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Choice Impulsivity: Definitions, measurement issues, and clinical implications
Personality Disorders: Theory, Research, and Treatment, 6, 182-198.
- Aggression as a Predictor of Early Substance Use Initiation among Youth with Family Histories of Substance Use Disorders
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Feasibility of a computer-assisted alcohol screening, brief intervention and referral to treatment program for DWI offenders
Addiction Science & Clinical Practice, 10, 1-10. Atlas of Science
- Treatment needs of driving while intoxicated offenders: The need for a multi-modal approach to treatment
- Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders
- Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders
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Increased forebrain activations in youths with family histories of alcohol and other Substance Use Disorders performing a Go/No Go Task
Alcoholism: Clinical and Experimental Research, 38, 2944-2951.
- Delay discounting differentiates pre-adolescents at high and low risk for substance use disorders based on family history
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Ethical considerations in adolescent drug research, a response to “Conflicting ethics of confidentiality in adolescent drug research”
Psychopharmacology, 231(8), 1433-1435. DOI: 10.1007/s00213-013-3183-9
- Stress, substance abuse, and addiction
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Problem identification and community assessment of DWI needs for Bexar County, Texas
Center for Medicare & Medicaid Services report 085144601.2.6: University of Texas Health Science Center San Antonio.
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Motivational interventions to reduce adult alcohol use/abuse and drunk driving incidents: A treatment manual for use in the criminal justice system
Center for Medicare & Medicaid Services report 085144601.2.6: University of Texas Health Science Center San Antonio.
- Impulsivity, attention, memory, and decision-making among adolescent marijuana users
- Adolescent attachment security, family functioning, and suicide attempts
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Acquisition of rater agreement for the Stressful Life Events Schedule
Journal of Alcoholism and Drug Dependence, 1:125, 1-5.
- What is the harm in asking about suicidal ideation?
- Psychopathic traits and their association with adjustment problems in girls.
- Intolerance to delayed reward in girls with multiple suicide attempts.
- Failure to sustain prepulse inhibition in adolescent marijuana users.
- Adults with a family history of alcohol related problems are more impulsive on measures of response initiation and response inhibition.
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Suicide and life-events
Suicide from a Global Perspective: Psychosocial Approaches (pp. 27-32). Nova Science Publishers Inc: Hauppauge, NY.
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Cognition and suicide
Suicide from a Global Perspective: Psychosocial Approaches (pp. 3-10). Nova Science Publishers Inc: Hauppauge, NY.
- Effects of acute tryptophan depletion on three types of behavioral impulsivity.
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Cognitive impairments in adolescent cannabis abusers are related to THC levels.
Addictive Behaviors and Their Treatment 9, 158-163.
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Sensitivity.
Encyclopedia of Research Design (pp. 3:1627-1628). Sage Publications, Inc: Thousand Oaks, CA.
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Specificity.
Encyclopedia of Research Design (pp. 3:1407-1408). Sage Publications, Inc: Thousand Oaks, CA.
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White Noise.
Encyclopedia of Research Design (pp. 3:1627-1628). Sage Publications, Inc: Thousand Oaks, CA.
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Impulsivity and clinical symptoms among adolescents with non-suicidal self-injury with or without attempted suicide.
Psychiatry Research, 169, 22-27
- Distinctions in behavioral impulsivity: Implications for substance abuse research.
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Fifty years of the Barratt Impulsiveness Scale: An update and review.
Personality and Individual Differences, 47, 385-395.
- Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter.
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The Adaptive Visual Analog Scales (AVAS): A modifiable software program for the creation, administration, and scoring of visual analog scales.
Behavior Research Methods, 41, 99-106.
- Differentiating impulsive and premeditated aggression: Self and informant perspectives among adolescents with personality pathology.
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L-tryptophan: Basic metabolic functions, behavioral research, and therapeutic indications.
International Journal of Tryptophan Research, 2, 45-60.
- Adolescent suicidal behavior and substance use: Developmental mechanisms
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Behavioral measures of impulsivity and the law.
Behavioral Sciences and the Law, 26, 691-707.
- A test of alcohol dose effects on multiple behavioral measures of impulsivity.
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Prospective study of cannabis withdrawal in cannabis-using adolescents.
Journal of the American Academy of Child and Adolescent Psychiatry, 47, 1095-1096.
- Comparison of 50g and 100g L-tryptophan depletion and loading formulations for altering 5-HT synthesis: Pharmacokinetics, side effects, and mood states.
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The biphasic effects of alcohol: Comparison of subjective and objective measures of stimulation, sedation, and physical activity.
Alcoholism: Clinical and Experimental Research, 31, 1883-1890
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The acute tryptophan depletion and loading tests: Specificity issues.
International Congress Series, 1304C, 159-166.
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Assessment of the kynurenine pathway in humans 1. Normal plasma values, ethnic differences, and their clinical implications.
International Congress Series, 1304C, 335-343.
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Impulsive and premeditated subtypes of aggression in Conduct Disorder: Differences in time estimation.
Aggressive Behavior, 33, 574-582
- The effects of alcohol on laboratory-measured impulsivity after L-Tryptophan depletion or loading.
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Behavioral impulsivity in adolescents with Conduct Disorder who use Marijuana.
Addictive Disorders and Their Treatment, 6, 43-50.
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Personality judgment and personality pathology: Self-other agreement in adolescents with Conduct Disorder.
Journal of Personality, 75, 629-662.
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Suicidal and nonsuicidal self-harm behaviors in adolescent substance use disorders.
In Y. Kaminer and O. Bukstein (Eds.), Adolescent Substance Abuse: Psychiatric Comorbidity and High Risk Behaviors (pp. 323-354).
Routledge, Taylor & Francis Group: New York, New York -
The relationship of inattentiveness, hyperactivity, and psychopathy among adolescents.
Personality and Individual Differences, 43, 1333-1343.
- Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with Conduct Disorder.
- Teenagers do not always lie: Characteristics and correspondence of telephone and in-person reports of adolescent drug use.
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Immediate and Delayed Memory Tasks.
In N. J. Salkind and K. Rasmussen (Eds.), The Encyclopedia of Measurement and Statistics Vol 2. (pp. 452-453).
Sage Publications; Thousand Oaks, California. -
Laboratory behavioral measures of impulsivity.
In N. J. Salkind and K. Rasmussen (Eds.), The Encyclopedia of Measurement and Statistics Vol 2. (pp. 525-526).
Sage Publications; Thousand Oaks, California. -
The conceptualization and role of impulsivity: Bipolar Disorder and Substance Abuse.
Psychiatric Times, 22, 32-35.
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Laboratory behavioral measures of impulsivity.
Behavior Research Methods, 37, 82-90.
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Age at first drink relates to behavioral measures of impulsivity: The Immediate and Delayed Memory Tasks.
Alcoholism: Clinical and Experimental Research, 28, 408-414.
- Laboratory measured behavioral impulsivity relates to suicide attempt history.
- P300 event related potential amplitude and impulsivity in cocaine dependent subjects.
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Obsessive-Compulsive Personality Disorder and behavioral disinhibition.
Journal of Psychology: Interdisciplinary and Applied, 138, 5-22.
- The physiological experience of the Paced Auditory Serial Addition Task (PASAT): Does the PASAT induce autonomic arousal?
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Behavioral impulsivity paradigms: A comparison in hospitalized adolescents with disruptive behavior disorders.
Journal of Child Psychology and Psychiatry and Allied Disciplines, 44, 1145-1157.
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Validation of the Immediate and Delayed Memory Tasks in hospitalized adolescents with disruptive behavior disorders.
Psychological Record, 53, 509-532.
- Familial transmission of continuous performance test behavior: Attentional and impulsive response characteristics.
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Laboratory measures of impulsivity.
In E. F. Coccaro (Ed.), Aggression: Psychiatric Assessment and Treatment. Medical Psychiatric Series No. 22,
Marcel Dekker Publishers: New York, New York. -
Commission error rates on a continuous performance test are related to deficits measured by the Benton Visual Retention Test.
Assessment, 10, 3-12.
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Comparability of the standard WCST and WCST-64 in traumatic brain injury.
Applied Neuropsychology, 10, 246-251
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Detecting malingered performance on the Wechsler Adult Intelligence Scale: Validation of Mittenberg’s approach in traumatic brain injury.
Archives of Clinical Neuropsychology, 18, 245-260.
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Impulsiveness and arousal: Heart rate under conditions of rest and challenge in healthy males.
Personality and Individual Differences, 35, 355-371.
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Characterizing aggressive behavior.
Assessment, 10, 183-190.
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Immediate and Delayed Memory Tasks: A computerized behavioral measure of memory, attention and impulsivity.
Behavior Research Methods, Instruments, & Computers, 34, 391-398.
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Laboratory measures of impulsivity: A comparison of women with and without childhood aggression.
The Psychological Record, 52, 289-303.
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Comparison of women with high and low trait impulsivity using laboratory impulsivity models of response-disinhibition and reward-choice.
Personality and Individual Differences, 33, 1291-1310.
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Temporal stability of the Wisconsin Card Sorting Test in a chronic traumatic brain injury sample.
Assessment, 9, 271-277.
- Wisconsin Card Sorting Test in chronic severe traumatic brain injury: Factor structure and performance subgroups.
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Detecting malingered performance with the Wisconsin Card Sorting Test: A preliminary investigation in traumatic brain injury.
The Clinical Neuropsychologist, 16, 179-191.
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Detecting malingered neurocognitive dysfunction using the Reliable Digit Span in traumatic brain injury.
The Clinical Neuropsychologist, Assessment, 9, 301-308.
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Cognitive strategy usage in long-term survivors of severe traumatic brain injury with persisting impulsive aggression.
Personality and Individual Differences, 32, 639-647.
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Symptom validity testing: A critical review.
The Clinical Neuropsychologist, 15, 19-45.
- Personality and neurocognitive correlates of impulsive aggression in long-term survivors of severe traumatic brain injury.
- A test of the psychometric characteristics of the BIS-Brief among three groups of youth