Donald M. Dougherty, Ph.D.
The William & Marguerite Wurzbach Distinguished Professor
Director, Neurobehavioral Research Division
Deputy Chair for Research, Department of Psychiatry
The University of Texas Health Science Center at San Antonio
Biographical Sketch
Dr. Dougherty is the William and Marguerite Wurzbach Distinguished Professor and Director of the Neurobehavioral Research Division within the Department of Psychiatry at The University of Texas Health Science Center at San Antonio. He also serves as the Director of the Neurobehavioral Research Laboratory and Clinic (NRLC) and Co-Director of the Research Residency Program. He completed his graduate training in Psychology at Ohio University and then held a National Institute for Drug Abuse sponsored postdoctoral research fellowship at The University of Texas Health Science Center at Houston (UTHSCH). After completing his training, Dr. Dougherty joined the faculty at UTHSCH, where the NRLC group was founded. After 12 years at UTHSCH, Dr. Dougherty and the NRLC research team moved to Wake Forest University Health Sciences in Winston-Salem, NC where Dr. Dougherty became Professor and Vice Chair for Research in the Department of Psychiatry. During his tenure as Vice Chair for Research, the Department of Psychiatry made significant progress toward the development of an interdisciplinary translational research program, which was evidenced by substantial increases in support from the National Institutes of Health and private donors. Seeing a great potential for expanding a translational research program to include interactions with community leaders within San Antonio, Dr. Dougherty and the NRLC research team returned to The University of Texas Health Sciences System in 2007. Dr. Dougherty's research interests are focused on understanding impulsive behaviors, with primary emphasis on problems associated with drug abuse and suicidality. Current projects include examining how drug abuse and early stressful life events adversely affect adolescent development of impulse control, and their relationship to the development of other adolescent psychopathology. Additionally, his interests include the identification of biological and behavioral risk factors for child and adult psychopathology. As an extension of this research, Dr. Dougherty and his colleagues have developed behavioral software paradigms for objectively assessing underlying mechanisms of different types of impulsive behavior. These paradigms have been validated in numerous studies and are freely available to other researchers. The long-term goals of the NRLC are to use information gathered from their research to inform the development of better treatment and community-based substance abuse prevention programs.
Research Interests
- Adolescent Development of Impulse Control
- Substance Use Initiation and Abuse
- Developmental Course of Suicidal Behaviors
- Identification and Measurement of Impulsive and Aggressive Behaviors
- Effects of Alcohol and Other Drugs of Abuse on Impulsive and Aggressive Behaviors
- Therapeutic Pharmacotherapy and their Effect on Behavioral Processes
- L-Tryptophan Depletion and Loading Methodologies
- Biological and Behavioral Markers and Neuroendocrine Challenge Procedures
- Behavioral Studies of Functional Magnetic Resonance Imaging
- Evaluation of Gender Differences in the above areas
- Development of Software and Paradigms for Objective Assessment of Behavior
Education
Year | Degree | Major | Institution |
---|---|---|---|
1995 | Fellowship | Substance Abuse | The University of Texas Medical School |
1992 | Ph.D. | Experimental Psychology | Ohio University |
1990 | M.S. | Experimental Psychology | Ohio University |
1985 | B.S. | Psychology | Bridgewater College |
Citation Record
- 6975 Times Cited
- 53 Citations per Publication
- 41 h-index
Presentations/Publications with the NRLC
-
The role of social support in motivating reductions in alcohol use: Tests of three models of social support in alcohol impaired drivers
Alcoholism: Clinical and Experimental Research, 43, 123-134.
- Laboratory measures of impulsivity.
- Time Delays in Transdermal Alcohol Concentrations Relative to Breath Alcohol Concentrations
- The correspondence between transdermal alcohol monitoring and daily self-reported alcohol consumption
- The potential clinical utility of transdermal alcohol monitoring data to estimate the number of alcoholic drinks consumed
-
Using contingency management procedures to reduce at-risk drinking in heavy drinkers
Alcoholism: Clinical and Experimental Research, 39, 109-121.
- Reliability estimates for the Immediate and Delayed Memory Tasks.
- Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol
- Preadolescent sensation seeking and early adolescent stress relate to at-risk adolescents’ substance use by age 15
-
Early adolescent trajectories of impulsiveness and sensation seeking in children of fathers with histories of alcohol and other substance use disorders
Alcoholism: Clinical & Experimental Research,. 40, 2,622-2,630
- Assessment of the human kynurenine pathway: Comparisons and clinical implications of ethnic and gender differences in plasma tryptophan, kynurenine metabolites, and enzyme expressions at baseline and after acute tryptophan loading and depletion.
- Acute effects of methylphenidate on impulsivity and attentional behavior in Comorbid ADHD and Conduct Disorder
- Child problems as a moderator of relations between maternal impulsivity and family environment in a high-risk sample.
-
Characterization of the pharmacokinetics of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 in human whole blood after alcohol consumption in a clinical laboratory study.
Alcoholism: Clinical and Experimental Research, 40, 1228-1234.
- Pubertal maturation compression and behavioral impulsivity among boys at increased risk for substance use
- Behavioral impulsivity does not predict naturalistic alcohol consumption or treatment outcomes
-
Clinical and social/environmental characteristics in a community sample of children with and without family histories of Substance Use Disorder in the San Antonio area: A descriptive study
Journal of Child and Adolescent Substance Abuse, 25, 327-339.
- Family functioning as a mediator of relations between family history of Substance Use Disorder and impulsivity
- Functional activation and effective connectivity differences in adolescent marijuana users performing a simulated gambling task
- Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance use disorders performing a go/no go task
- Standardization of formulations for the acute amino acid depletion and loading tests.
- Increased Pre- and Early-Adolescent Stress in Youth with a Family History of Substance Use Disorder and Early Substance Use Initiation
- Childhood stress exposure among preadolescents with and without family histories of substance use disorders
- Transdermal alcohol concentration data collected during a contingency management program to reduce at-risk drinking
- Behavioral impulsivity and risk-taking trajectories across early adolescence in youths with and without family histories of alcohol and other drug use disorders
- Effects of tryptophan depletion and a simulated alcohol binge on impulsivity.
- Accounting for sex-related differences in the estimation of breath alcohol levels using transdermal alcohol monitoring
- Assessing the validity of participant-derived compared to staff-derived values to compute a binge score
- Aggression as a Predictor of Early Substance Use Initiation among Youth with Family Histories of Substance Use Disorders
-
Feasibility of a computer-assisted alcohol screening, brief intervention and referral to treatment program for DWI offenders
Addiction Science & Clinical Practice, 10, 1-10. Atlas of Science
- Treatment needs of driving while intoxicated offenders: The need for a multi-modal approach to treatment
-
Using transdermal alcohol monitoring to detect low-level drinking
Alcoholism: Clinical & Experimental Research, 39, 1120-1127.
-
Increased forebrain activations in youths with family histories of alcohol and other Substance Use Disorders performing a Go/No Go Task
Alcoholism: Clinical and Experimental Research, 38, 2944-2951.
- Mechanisms of the pellagragenic effect of leucine: stimulation of hepatic tryptophan oxidation by administration of branched-chain amino acids to healthy human volunteers and the role of plasma free tryptophan and total kynurenines.
- Delay discounting differentiates pre-adolescents at high and low risk for substance use disorders based on family history
- Use of continuous transdermal alcohol monitoring during a contingency management procedure to reduce excessive alcohol use.
-
Ethical considerations in adolescent drug research, a response to “Conflicting ethics of confidentiality in adolescent drug research”
Psychopharmacology, 231(8), 1433-1435. DOI: 10.1007/s00213-013-3183-9
- Stress, substance abuse, and addiction
-
Do variable rates of alcohol drinking alter the ability to use transdermal alcohol monitors to estimate peak breath alcohol and total number of drinks?
Alcoholism: Clinical and Experimental Research, 38, 2517-2522.
- Accounting for sex-related differences in the estimation of breath alcohol concentrations using transdermal alcohol monitoring
-
Problem identification and community assessment of DWI needs for Bexar County, Texas
Center for Medicare & Medicaid Services report 085144601.2.6: University of Texas Health Science Center San Antonio.
- Impulsivity, attention, memory, and decision-making among adolescent marijuana users
- Adolescent attachment security, family functioning, and suicide attempts
-
Acquisition of rater agreement for the Stressful Life Events Schedule
Journal of Alcoholism and Drug Dependence, 1:125, 1-5.
- Continuous objective monitoring of alcohol use: Twenty-first century measurement using transdermal sensors.
- What is the harm in asking about suicidal ideation?
- Psychopathic traits and their association with adjustment problems in girls.
- Comparing the detection of transdermal and breath alcohol concentrations during periods of alcohol consumption ranging from moderate drinking to binge drinking.
- Intolerance to delayed reward in girls with multiple suicide attempts.
- Failure to sustain prepulse inhibition in adolescent marijuana users.
- Adults with a family history of alcohol related problems are more impulsive on measures of response initiation and response inhibition.
-
Suicide and life-events
Suicide from a Global Perspective: Psychosocial Approaches (pp. 27-32). Nova Science Publishers Inc: Hauppauge, NY.
-
Cognition and suicide
Suicide from a Global Perspective: Psychosocial Approaches (pp. 3-10). Nova Science Publishers Inc: Hauppauge, NY.
- Effects of acute tryptophan depletion on three types of behavioral impulsivity.
-
Cognitive impairments in adolescent cannabis abusers are related to THC levels.
Addictive Behaviors and Their Treatment 9, 158-163.
-
Specificity of the acute Tryptophan and Tyrosine plus Phenylalanine depletion and loading tests Part I. Review of biochemical aspects and poor specificity of current amino acid formulations.
International Journal of Tryptophan Research, 3, 23-34.
-
Specificity of the acute Tryptophan and Tyrosine plus Phenylalanine depletion and loading tests Part II. Normalisation of the Tryptophan and Tyrosine plus Phenylalanine to competing amino acid ratios in a new control formulation.
International Journal of Tryptophan Research, 3, 35-47.
-
Impulsivity and clinical symptoms among adolescents with non-suicidal self-injury with or without attempted suicide.
Psychiatry Research, 169, 22-27
- Distinctions in behavioral impulsivity: Implications for substance abuse research.
-
Fifty years of the Barratt Impulsiveness Scale: An update and review.
Personality and Individual Differences, 47, 385-395.
- Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter.
- Activation of liver Tryptophan Pyrolase mediates the decrease in Tryptophan availability to the brain after acute alcohol consumption in normal subjects.
-
The Adaptive Visual Analog Scales (AVAS): A modifiable software program for the creation, administration, and scoring of visual analog scales.
Behavior Research Methods, 41, 99-106.
- Candidate endophenotypes for genetic studies of suicidal behavior.
- Differentiating impulsive and premeditated aggression: Self and informant perspectives among adolescents with personality pathology.
-
L-tryptophan: Basic metabolic functions, behavioral research, and therapeutic indications.
International Journal of Tryptophan Research, 2, 45-60.
- Adolescent suicidal behavior and substance use: Developmental mechanisms
-
Behavioral measures of impulsivity and the law.
Behavioral Sciences and the Law, 26, 691-707.
- A test of alcohol dose effects on multiple behavioral measures of impulsivity.
-
Prospective study of cannabis withdrawal in cannabis-using adolescents.
Journal of the American Academy of Child and Adolescent Psychiatry, 47, 1095-1096.
- Comparison of 50g and 100g L-tryptophan depletion and loading formulations for altering 5-HT synthesis: Pharmacokinetics, side effects, and mood states.
-
The biphasic effects of alcohol: Comparison of subjective and objective measures of stimulation, sedation, and physical activity.
Alcoholism: Clinical and Experimental Research, 31, 1883-1890
-
The acute tryptophan depletion and loading tests: Specificity issues.
International Congress Series, 1304C, 159-166.
-
Assessment of the kynurenine pathway in humans 1. Normal plasma values, ethnic differences, and their clinical implications.
International Congress Series, 1304C, 335-343.
-
Impulsive and premeditated subtypes of aggression in Conduct Disorder: Differences in time estimation.
Aggressive Behavior, 33, 574-582
- The effects of alcohol on laboratory-measured impulsivity after L-Tryptophan depletion or loading.
-
Behavioral impulsivity in adolescents with Conduct Disorder who use Marijuana.
Addictive Disorders and Their Treatment, 6, 43-50.
-
Personality judgment and personality pathology: Self-other agreement in adolescents with Conduct Disorder.
Journal of Personality, 75, 629-662.
-
Suicidal and nonsuicidal self-harm behaviors in adolescent substance use disorders.
In Y. Kaminer and O. Bukstein (Eds.), Adolescent Substance Abuse: Psychiatric Comorbidity and High Risk Behaviors (pp. 323-354).
Routledge, Taylor & Francis Group: New York, New York -
The relationship of inattentiveness, hyperactivity, and psychopathy among adolescents.
Personality and Individual Differences, 43, 1333-1343.
- Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with Conduct Disorder.
- Teenagers do not always lie: Characteristics and correspondence of telephone and in-person reports of adolescent drug use.
-
Manic symptoms and impulsivity during bipolar depressive episodes.
Bipolar Disorders, 9, 206-212
- Cannabis withdrawal among adolescent cannabis users in an outpatient research setting.
-
Immediate and Delayed Memory Tasks.
In N. J. Salkind and K. Rasmussen (Eds.), The Encyclopedia of Measurement and Statistics Vol 2. (pp. 452-453).
Sage Publications; Thousand Oaks, California. -
Laboratory behavioral measures of impulsivity.
In N. J. Salkind and K. Rasmussen (Eds.), The Encyclopedia of Measurement and Statistics Vol 2. (pp. 525-526).
Sage Publications; Thousand Oaks, California. -
Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects.
Psychiatry Research: Neuroimaging, 147, 239-242.
-
The conceptualization and role of impulsivity: Bipolar Disorder and Substance Abuse.
Psychiatric Times, 22, 32-35.
-
Laboratory behavioral measures of impulsivity.
Behavior Research Methods, 37, 82-90.
- Acute yohimbine increases laboratory-measured impulsivity in normal subjects.
- Increased impulsivity associated with severity of suicide attempt history in patients with Bipolar Disorder.
-
Age at first drink relates to behavioral measures of impulsivity: The Immediate and Delayed Memory Tasks.
Alcoholism: Clinical and Experimental Research, 28, 408-414.
- Laboratory measured behavioral impulsivity relates to suicide attempt history.
- Overview of workshop on drug abuse and suicidal behavior.
- P300 event related potential amplitude and impulsivity in cocaine dependent subjects.
-
Impulsivity: A link between bipolar disorder and substance abuse.
Bipolar Disorders, 6, 204-212.
-
Behavioral impulsivity paradigms: A comparison in hospitalized adolescents with disruptive behavior disorders.
Journal of Child Psychology and Psychiatry and Allied Disciplines, 44, 1145-1157.
-
Validation of the Immediate and Delayed Memory Tasks in hospitalized adolescents with disruptive behavior disorders.
Psychological Record, 53, 509-532.
- Familial transmission of continuous performance test behavior: Attentional and impulsive response characteristics.
-
Laboratory measures of impulsivity.
In E. F. Coccaro (Ed.), Aggression: Psychiatric Assessment and Treatment. Medical Psychiatric Series No. 22,
Marcel Dekker Publishers: New York, New York. -
Commission error rates on a continuous performance test are related to deficits measured by the Benton Visual Retention Test.
Assessment, 10, 3-12.
-
Psychopathology among persons responding to participation as normal controls in behavioral research studies.
Comprehensive Psychiatry, 44, 83-87.
- Impulsivity and phase of illness in bipolar disorder.
-
The serotonin 2a receptor T102C polymorphism and impaired impulse control.
American Journal of Medical Genetics (Neuropsychiatric Genetics), 114, 336-339.
- Possible amotivational effects following marijuana smoking under laboratory conditions.
-
Immediate and Delayed Memory Tasks: A computerized behavioral measure of memory, attention and impulsivity.
Behavior Research Methods, Instruments, & Computers, 34, 391-398.
-
Laboratory measures of impulsivity: A comparison of women with and without childhood aggression.
The Psychological Record, 52, 289-303.
- Laboratory-measured aggressive behavior of women: Acute tryptophan depletion and augmentation
-
Comparison of women with high and low trait impulsivity using laboratory impulsivity models of response-disinhibition and reward-choice.
Personality and Individual Differences, 33, 1291-1310.
- Impulsivity and substance abuse: What is the connection?
-
Heavy “Ecstasy” use is associated with increased impulsivity.
Addictive Disorders and Their Treatment, 1, 47-52.
-
Two models of impulsivity: Relationship to personality traits and psychopathology.
Biological Psychiatry, 51, 988-994.
-
Endogenous plasma testosterone levels and commission errors in women: A preliminary report.
Physiology and Behavior, 73, 217-221.
-
The impact of impulsivity on cocaine use and retention in treatment.
Journal of Substance Abuse Treatment,21, 193-198.
-
Measurement of inter-episode impulsivity in bipolar disorder.
Psychiatry Research, 101, 195-197.
-
Effects of Moderate and High Doses of Alcohol on Attention, Impulsivity, Discriminability, and Response Bias in Immediate and Delayed Memory Task Performance.
Alcoholism: Clinical and Experimental Research, 24, 1702-1711.
-
A comparison between adults with conduct disorder and normal controls on a Continuous Performance Test: Differences in impulsive response characteristics.
The Psychological Record, 50, 203-219.
- A test of the psychometric characteristics of the BIS-Brief among three groups of youth